The Seasonal School: “Secretion in Heath & Disease. Neurological Disorders to Diabetes” will be held in 1-9 May, 2017, at Ilia State University and I. Beritashvili Center of Experimental Biomedicine. Participants will be 20 scientists: young researchers, PhD and master students from different universities and scientific organizations of Georgia. The main purpose of School is to give to participants the knowledge about molecular mechanisms of cell secretion, to discuss the pathologies associated with disorders of cell secretion, and to analyze how it will be possible to prevent/cure such pathologies on molecular/nanoscale level. The theoretical lectures and practical/laboratory studies will on (i) electron microscopy and (ii) atomic force microscopy will be offered. The lecturers will be: Professor Dr. Bhanu Jena (Wayne State University, USA); Dr. Sandor Kasas, (Institute of Technology of Lausanne, Switzerland); Professor Dr. Ia Zhvania (Ilia State University, Ivane Beritashvili Center of Experimental Biomedicine); Professor Dr. Nadezhda Japaridze (New Vision University, Ivane Beritashvili Center of Experimental Biomedicine,); Associate Professor Dr. Tamar Lordkipanidze (Ilia State University, Ivane Beritashvili Center of Experimental Biomedicine); Associate Professor Dr. Tamar Bikashvili (Ivane Beritashvili Center of Experimental Biomedicine, New Vision University); Giorgi Tsertsvadze, PhD (George Eliava Institute of Bacterophage, Microbiology and Virology); David Khutsishvili, MD (Georgian Technical University); Micheil Mebonia, MD (Ilia State University).
In the case of particular interest, the participants of the School will be involved in corresponding scientific research performed in the Institute of Chemical Biology Ilia State University and Laboratory of Brain Ultrastructure and Nanoarchitecture Ivane Beritashvili Center of Experimental Biomedicine.
The organizers believe that such School will be of great benefit to both, the research and academic community of Georgia.
The lectures that will be present in this course are based on cutting edge and recent discoveries listed below:
i. A Voyage Through Time & Space: Atomic Force Microscopy, and the birth of Nano Cell Biology.
ii. Historical overview of the Secretion & Membrane Fusion.
iii. New Cellular Structures at the Plasma Membrane of Exocrine Pancreas are ‘Secretory Portals’ or ‘Porosomes’.
iv. Composition and Functional Reconstitution of ‘Porosomes’ in Artificial Lipid Membrane.
v. Porosomes in Neurons and in Endocrine Cells.
vi. Porosome in Cystic Fibrosis.
vii. Membrane-Associated SNAREs and their Involvement in Calcium-Mediated Membrane Fusion.
viii. Role of Lipids on the Structure and Assembly of SNAREs.
ix. Secretory Vesicle Volume Increase is a Requirement for the Regulated Expulsion of Intravesicular Contents from Cells during Cell Secretion.
x. The Molecular Mechanism of Secretory Vesicle Volume Regulation in Cells.
xi. Role of pH on Cell Secretion.
xii. Biogenesis of Biological Membranes.
xiii. Single Molecular Thermometry.
xiv. The Ultrastructure of Neurons, Glial Cells and Synapses: Electron Microscopy Resolves the Fine Structure of Cell.
xv. The Ultrastructure of Neurons, Synapses and Glial Cells and Neurological Pathologies.
xvi. The Ultrastructure of Neuronal Porosomal Complex in Norm and Pathologies.
xvii. Atomic Force Microscopy – Nanoscale Technology for Cell Studies.
xviii. The Development of Neurons, Glial Cells and Synapses – Ultrastructural and Other Fine Structural Peculiarities.